Automated description from the Alliance of Genome Resources (Release 4.0)
Enables several functions, including ATP hydrolysis activity; DNA polymerase binding activity; and nucleic acid binding activity. Involved in nervous system development; positive regulation of Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including animal organ development; blastocyst development; and circulatory system development. Located in euchromatin; heterochromatin; and perichromatin fibrils. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study breast cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4).