Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bmp6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bmp6
  • participates in the following biological processes:
    • BMP signaling pathway ^{[2, 4]}
    • positive regulation of endothelial cell differentiation ^[9]
    • positive regulation of endothelial cell proliferation ^[9]
    • positive regulation of neuron differentiation ^[3]
• The gene product of Bmp6 has been shown to bind to the gene products of Bmper, Chrdl2. ^{[2, 5, 6]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bmp6
  • participates in the following biological processes:
    • cell differentiation ^[10]
    • endochondral ossification ^[8]
• Researchers have inferred, based on genetic interactions, that the gene product of Bmp6
  • participates in the following biological processes:
    • eye development based on interactions with Bmp7 ^[7]
    • kidney development based on interactions with Bmp7 ^[7]
    • male genitalia development based on interactions with Bmp5 ^[8]
    • osteoblast differentiation based on interactions with Bmp2 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bmp6:
  • participates in the following biological processes:
    • BMP signaling pathway
    • immune response
    • positive regulation of aldosterone biosynthetic process
    • positive regulation of bone mineralization
    • positive regulation of epithelial cell proliferation
    • positive regulation of osteoblast differentiation
    • positive regulation of pathway-restricted SMAD protein phosphorylation
    • positive regulation of transcription from RNA polymerase II promoter
    • SMAD protein signal transduction
    • type B pancreatic cell development
  • performs the following molecular functions:
    • BMP receptor binding
    • growth factor activity
    • protein heterodimerization activity
  • is located in the following cellular components:
    • cytoplasm
    • extracellular space
    • membrane-bounded vesicle

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Summary text based on GO annotations supported by structural data

• Bmp6 encodes a protein or proteins that contain the following InterPro domains: Inhibin, alpha subunit, Transforming growth factor beta, conserved site, Transforming growth factor-beta, C-terminal, Transforming growth factor-beta, N-terminal, Transforming growth factor-beta-related, indicating that the gene product:
  • participates in the following biological processes:
    • growth
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bmp6 indicates that it:
  • participates in the following biological processes:
    • cartilage development
    • multicellular organismal development
    • ossification
  • performs the following molecular functions:
    • cytokine activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Kugimiya F et al. (2005) Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem, 280:35704-12. (PubMed:16109715)
2. Laurikkala J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol, 264:91-105. (PubMed:14623234)
3. Li W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J Neurosci, 18:8853-62. (PubMed:9786991)
4. Miwa H et al. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS Lett, 583:3643-8. (PubMed:19852960)
5. Moser M et al. (2003) BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol, 23:5664-79. (PubMed:12897139)
6. Nakayama N et al. (2004) A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Development, 131:229-40. (PubMed:14660436)
7. Oxburgh L et al. (2005) BMP4 substitutes for loss of BMP7 during kidney development. Dev Biol, 286:637-46. (PubMed:16154126)
8. Solloway MJ et al. (1998) Mice lacking Bmp6 function. Dev Genet, 22:321-39. (PubMed:9664685)
9. Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci, 123:1684-92. (PubMed:20406889)
10. Yang Z et al. (2003) Math5 determines the competence state of retinal ganglion cell progenitors. Dev Biol, 264:240-54. (PubMed:14623245)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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