GO Annotations Graph

• Symbol: Bmp6
• Name: bone morphogenetic protein 6
• ID: MGI:88182

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070700	BMP receptor binding	IBA	J:265628
Molecular Function	GO:0070700	BMP receptor binding	ISO	J:22224
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:84799
Molecular Function	GO:0005515	protein binding	IPI	J:86665
Molecular Function	GO:0005515	protein binding	IPI	J:87049
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:22224
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:151027
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:154664
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:86665
Biological Process	GO:0060348	bone development	ISO	J:164563
Biological Process	GO:0051216	cartilage development	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0031668	cellular response to extracellular stimulus	TAS	J:222266
Biological Process	GO:0071281	cellular response to iron ion	IMP	J:151027
Biological Process	GO:0001958	endochondral ossification	IMP	J:48561
Biological Process	GO:0001654	eye development	IGI	J:103587
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IEP	J:116258
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:151027
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:174000
Biological Process	GO:0001822	kidney development	IGI	J:103587
Biological Process	GO:0030539	male genitalia development	IGI	J:48561
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:151027
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	ISO	J:164563
Biological Process	GO:1903392	negative regulation of adherens junction organization	ISO	J:164563
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:151027
Biological Process	GO:0030182	neuron differentiation	IMP	J:86669
Biological Process	GO:0001503	ossification	ISO	J:155856
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:102448
Biological Process	GO:0032349	positive regulation of aldosterone biosynthetic process	ISO	J:164563
Biological Process	GO:2000860	positive regulation of aldosterone secretion	ISO	J:155856
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	ISO	J:155856
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	IDA	J:164086
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	IDA	J:164086
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	IMP	J:151027
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:50621
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP	J:151027
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA	J:265628
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	IMP	J:151027
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:151027
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IMP	J:151027
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0003323	type B pancreatic cell development	ISO	J:164563