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Gene Ontology Classifications
activating transcription factor 4

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atf4. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Allen-Jennings AE et al. (2002) The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression. J Biol Chem, 277:20020-5. (PubMed:11916968)
  2. Ambivero CT et al. (2012) ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway. Biochim Biophys Acta, 1823:2149-56. (PubMed:22974638)
  3. Bouman L et al. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ, 18:769-82. (PubMed:21113145)
  4. Csibi A et al. (2013) The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell, 153:840-54. (PubMed:23663782)
  5. Dobreva G et al. (2006) SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell, 125:971-86. (PubMed:16751105)
  6. Elefteriou F et al. (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature, 434:514-20. (PubMed:15724149)
  7. Galehdar Z et al. (2010) Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci, 30:16938-48. (PubMed:21159964)
  8. Jiang HY et al. (2004) Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol, 24:1365-77. (PubMed:14729979)
  9. Kawai T et al. (2003) ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Mol Cell Biol, 23:6174-86. (PubMed:12917339)
  10. Kawai T et al. (1998) ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol, 18:1642-51. (PubMed:9488481)
  11. Koyanagi S et al. (2011) cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem, 286:32416-23. (PubMed:21768648)
  12. Luo S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J Biol Chem, 278:37375-85. (PubMed:12871976)
  13. Nishizawa M et al. (1992) cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. FEBS Lett, 299:36-8. (PubMed:1371974)
  14. Ohoka N et al. (2005) TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J, 24:1243-55. (PubMed:15775988)
  15. Ord D et al. (2003) Mouse NIPK interacts with ATF4 and affects its transcriptional activity. Exp Cell Res, 286:308-20. (PubMed:12749859)
  16. Ritter B et al. (2004) The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development. Brain Res Dev Brain Res, 149:73-7. (PubMed:15013631)
  17. Roybal CN et al. (2005) The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. J Biol Chem, 280:20331-9. (PubMed:15788408)
  18. Yu VW et al. (2009) FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes. Gene Expr Patterns, null:null. (PubMed:19232401)
  19. Yu VW et al. (2005) FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. J Cell Biol, 169:591-601. (PubMed:15911876)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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