Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables type 1 angiotensin receptor binding activity and type 2 angiotensin receptor binding activity. Involved in aldosterone secretion; positive regulation of epithelial to mesenchymal transition; and positive regulation of transforming growth factor beta1 activation. Acts upstream of or within several processes, including positive regulation of cellular biosynthetic process; positive regulation of intracellular signal transduction; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).