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Gene Ontology Classifications
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Agt. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 5, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
  1. Akishita M et al. (1999) Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun, 261:345-9. (PubMed:10425188)
  2. Daubert DL et al. (1999) Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption. Brain Res, 816:8-16. (PubMed:9878677)
  3. Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE, 4:e5406. (PubMed:19404405)
  4. Hefler LA et al. (2001) Influence of the angiotensinogen gene on the ovulatory capacity of mice. Fertil Steril, 75:1206-11. (PubMed:11384650)
  5. Iosipiv IV et al. (2003) A role for angiotensin II AT1 receptors in ureteric bud cell branching. Am J Physiol Renal Physiol, 285:F199-207. (PubMed:12657564)
  6. Itoh S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation, 113:1787-98. (PubMed:16585392)
  7. Kakinuma Y et al. (1997) Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett, 232:167-70. (PubMed:9310306)
  8. Kakinuma Y et al. (1998) Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nat Med, 4:1078-80. (PubMed:9734405)
  9. Kazama K et al. (2004) Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res, 95:1019-26. (PubMed:15499027)
  10. Kihara M et al. (1998) Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int, 53:548-55. (PubMed:9507198)
  11. Kim HS et al. (1999) Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J Biol Chem, 274:14210-7. (PubMed:10318840)
  12. Kim S et al. (2002) Effects of High-Fat Diet, Angiotensinogen (agt) Gene Inactivation, and Targeted Expression to Adipose Tissue on Lipid Metabolism and Renal Gene Expression. Horm Metab Res, 34:721-5. (PubMed:12660889)
  13. Massiera F et al. (2001) Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J, 15:2727-9. (PubMed:11606482)
  14. Miyazaki Y et al. (1998) Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest, 102:1489-97. (PubMed:9788961)
  15. Niimura F et al. (1995) Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest, 96:2947-54. (PubMed:8675666)
  16. Nyui N et al. (1997) Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice. Biochem Biophys Res Commun, 235:36-41. (PubMed:9196031)
  17. Park K et al. (2013) Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol, 33:3227-41. (PubMed:23775122)
  18. Peng X et al. (2006) Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest, 116:217-27. (PubMed:16374517)
  19. Sun Z et al. (2003) Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension, 41:322-7. (PubMed:12574102)
  20. Tamura K et al. (1999) Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice. J Endocrinol, 160:401-8. (PubMed:10076178)
  21. Taniguchi K et al. (1998) Pathologic characterization of hypotensive C57BL/6J-agt: angiotensinogen-deficient C57BL/6J mice. Int J Mol Med, 1:583-7. (PubMed:9852267)
  22. Tanimoto K et al. (1994) Angiotensinogen-deficient mice with hypotension. J Biol Chem, 269:31334-7. (PubMed:7989296)
  23. Tsuchida S et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest, 101:755-60. (PubMed:9466969)
  24. Umemura S et al. (1998) Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading. J Hypertens, 16:285-9. (PubMed:9557921)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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