Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dock8. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]

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Summary text based on GO annotations supported by structural data

• Dock8 encodes a protein or proteins that contain the following InterPro domains: Dedicator of cytokinesis, Dedicator of cytokinesis C, Dedicator of cytokinesis C-terminal, Dedicator of cytokinesis C/D, N-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • small GTPase mediated signal transduction
  • performs the following molecular functions:
    • guanyl-nucleotide exchange factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dock8 indicates that it:
  • performs the following molecular functions:
    • guanyl-nucleotide exchange factor activity
• Annotations directly to cellular component for the gene Dock8 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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