Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits D1 dopamine receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; neurotransmitter receptor transport, endosome to postsynaptic membrane; and positive regulation of cell communication. Localizes to several cellular components, including glutamatergic synapse; postsynaptic density; and retromer complex. Predicted to colocalize with mitochondrion. Used to study Parkinson's disease 17. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human VPS35 (VPS35 retromer complex component).