GO Annotations Graph

• Symbol: Vps35
• Name: VPS35 retromer complex component
• ID: MGI:1890467

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031748	D1 dopamine receptor binding	IPI	J:235288
Molecular Function	GO:0031748	D1 dopamine receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:233567
Molecular Function	GO:0005515	protein binding	IPI	J:136228
Molecular Function	GO:0005515	protein binding	IPI	J:225406
Molecular Function	GO:0005515	protein binding	IPI	J:235288
Molecular Function	GO:0005515	protein binding	IPI	J:245266
Molecular Function	GO:0005515	protein binding	IPI	J:167062
Molecular Function	GO:0005515	protein binding	IPI	J:182936
Molecular Function	GO:0005515	protein binding	IPI	J:198162
Molecular Function	GO:0005515	protein binding	IPI	J:251210
Molecular Function	GO:0005515	protein binding	IPI	J:215242
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Cellular Component	GO:0005737	cytoplasm	IDA	J:225408
Cellular Component	GO:0005737	cytoplasm	IMP	J:225806
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:274797
Cellular Component	GO:0098691	dopaminergic synapse	IEP	J:274797
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:274797
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:274797
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IDA	J:236595
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:256145
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:256145
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:256145
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:256145
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:256145
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263408
Cellular Component	GO:0005770	late endosome	IBA	J:265628
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISA	J:66223
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0099073	mitochondrion-derived vesicle	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	IMP	J:225806
Cellular Component	GO:0043025	neuronal cell body	IMP	J:225806
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IMP	J:225806
Cellular Component	GO:0098794	postsynapse	IEP	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263408
Cellular Component	GO:0098794	postsynapse	IEP	J:263408
Cellular Component	GO:0098794	postsynapse	IPI	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263408
Cellular Component	GO:0098794	postsynapse	IPI	J:263408
Cellular Component	GO:0098794	postsynapse	IPI	J:263408
Cellular Component	GO:0098794	postsynapse	IMP	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263408
Cellular Component	GO:0098794	postsynapse	IMP	J:263408
Cellular Component	GO:0098794	postsynapse	IPI	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263408
Cellular Component	GO:0098794	postsynapse	IDA	J:263203
Cellular Component	GO:0098794	postsynapse	IDA	J:263203
Cellular Component	GO:0098794	postsynapse	IDA	J:263203
Cellular Component	GO:0098794	postsynapse	IDA	J:263203
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0098793	presynapse	IDA	J:263203
Cellular Component	GO:0098793	presynapse	IDA	J:263203
Cellular Component	GO:0098793	presynapse	IDA	J:263203
Cellular Component	GO:0098793	presynapse	IDA	J:263203
Cellular Component	GO:0098793	presynapse	IDA	J:263203
Cellular Component	GO:0098793	presynapse	IDA	J:263203
Cellular Component	GO:0098793	presynapse	IDA	J:263203
Cellular Component	GO:0098793	presynapse	IDA	J:263203
Cellular Component	GO:0030904	retromer complex	ISO	J:164563
Cellular Component	GO:0030904	retromer complex	IDA	J:167062
Cellular Component	GO:0030904	retromer complex	ISO	J:155856
Cellular Component	GO:0030904	retromer complex	IBA	J:265628
Cellular Component	GO:0030906	retromer, cargo-selective complex	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:251210
Cellular Component	GO:0097422	tubular endosome	ISO	J:164563
Biological Process	GO:0032456	endocytic recycling	ISO	J:164563
Biological Process	GO:0006886	intracellular protein transport	IBA	J:265628
Biological Process	GO:0007040	lysosome organization	IMP	J:225806
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	ISO	J:164563
Biological Process	GO:0099074	mitochondrion to lysosome transport	ISO	J:164563
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:274797
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IEP	J:274797
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:274797
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:274797
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:225806
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:225806
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:1902823	negative regulation of late endosome to lysosome transport	ISO	J:164563
Biological Process	GO:1905166	negative regulation of lysosomal protein catabolic process	IMP	J:225806
Biological Process	GO:1901215	negative regulation of neuron death	IMP	J:225806
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:0032463	negative regulation of protein homooligomerization	IMP	J:225806
Biological Process	GO:1903828	negative regulation of protein localization	IMP	J:225806
Biological Process	GO:0099639	neurotransmitter receptor transport, endosome to plasma membrane	ISO	J:164563
Biological Process	GO:0099639	neurotransmitter receptor transport, endosome to plasma membrane	IMP	J:235288
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA	J:256145
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA	J:256145
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA	J:256145
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA	J:256145
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP	J:256145
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IGI	J:225408
Biological Process	GO:1903181	positive regulation of dopamine biosynthetic process	IMP	J:225806
Biological Process	GO:0060161	positive regulation of dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:225806
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:225806
Biological Process	GO:0090326	positive regulation of locomotion involved in locomotory behavior	IMP	J:225806
Biological Process	GO:0090141	positive regulation of mitochondrial fission	ISO	J:164563
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0061357	positive regulation of Wnt protein secretion	IMP	J:225406
Biological Process	GO:0031648	protein destabilization	IMP	J:225806
Biological Process	GO:0036010	protein localization to endosome	ISO	J:164563
Biological Process	GO:0033365	protein localization to organelle	IMP	J:225806
Biological Process	GO:0015031	protein transport	IEA	J:72247
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:1902950	regulation of dendritic spine maintenance	ISO	J:164563
Biological Process	GO:0010821	regulation of mitochondrion organization	ISO	J:164563
Biological Process	GO:0150052	regulation of postsynapse assembly	IMP	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IDA	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IDA	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IDA	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IDA	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IDA	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IDA	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IMP	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IMP	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IDA	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IMP	J:263408
Biological Process	GO:0150052	regulation of postsynapse assembly	IDA	J:263408
Biological Process	GO:0051246	regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0090128	regulation of synapse maturation	IMP	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IMP	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IMP	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IMP	J:263408
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:263408
Biological Process	GO:2000331	regulation of terminal button organization	ISO	J:164563
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	ISO	J:164563
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	IC	J:225806
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	ISO	J:155856
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	IBA	J:265628
Biological Process	GO:0045056	transcytosis	ISO	J:164563
Biological Process	GO:0006624	vacuolar protein processing	ISA	J:66223
Biological Process	GO:0099003	vesicle-mediated transport in synapse	IDA	J:256145
Biological Process	GO:0099003	vesicle-mediated transport in synapse	IDA	J:256145
Biological Process	GO:0099003	vesicle-mediated transport in synapse	IDA	J:256145
Biological Process	GO:0099003	vesicle-mediated transport in synapse	IMP	J:256145
Biological Process	GO:0099003	vesicle-mediated transport in synapse	IDA	J:256145
Biological Process	GO:0050882	voluntary musculoskeletal movement	IMP	J:225806