Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits leptin receptor activity. Involved in several processes, including energy homeostasis; negative regulation of gluconeogenesis; and positive regulation of cold-induced thermogenesis. Predicted to localize to external side of plasma membrane; extracellular space; and receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and musculoskeletal system. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and osteoporosis. Orthologous to human LEPR (leptin receptor).