Automated description from the Alliance of Genome Resources
Exhibits leptin receptor activity. Involved in several processes, including energy homeostasis; negative regulation of gluconeogenesis; and positive regulation of cold-induced thermogenesis. Predicted to localize to the external side of plasma membrane; extracellular space; and receptor complex. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; non-alcoholic fatty liver disease; obesity; obstructive sleep apnea; and osteoporosis. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and musculoskeletal system. Orthologous to human LEPR (leptin receptor).