Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lepr. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on genetic interactions, that the gene product of Lepr
  • participates in the following biological processes:
    • cholesterol metabolic process based on interactions with Apoa1 ^[1]
    • negative regulation of hydrolase activity based on interactions with Apoa1 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lepr:
  • participates in the following biological processes:
    • angiogenesis
    • eating behavior
    • leptin-mediated signaling pathway
    • positive regulation of MAPK cascade
  • performs the following molecular functions:
    • peptide hormone binding
    • protein-hormone receptor activity
  • is located in the following cellular components:
    • extracellular space
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Lepr encodes a protein or proteins that contain the following InterPro domains: Fibronectin, type III, Immunoglobulin C2-set-like, ligand-binding, Immunoglobulin-like, Immunoglobulin-like fold, Leptin receptor, Long hematopoietin receptor, Gp130 family 2, conserved site, Short hematopoietin receptor, family 1, conserved site, indicating that the gene product:
  • performs the following molecular functions:
    • cytokine receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lepr indicates that it:
  • is located in the following cellular components:
    • extracellular region
    • integral to membrane
    • membrane

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References

1. Gruen ML et al. (2005) Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res, 46:2007-14. (PubMed:15995171)
2. Seo S et al. (2009) Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet, 18:1323-31. (PubMed:19150989)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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