GO Annotations Graph

• Symbol: Lepr
• Name: leptin receptor
• ID: MGI:104993

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019955	cytokine binding	IBA	J:265628
Molecular Function	GO:0004896	cytokine receptor activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0038021	leptin receptor activity	IMP	J:82334
Molecular Function	GO:0038021	leptin receptor activity	ISO	J:164563
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:109624
Molecular Function	GO:0005515	protein binding	IPI	J:247403
Molecular Function	GO:0005515	protein binding	IPI	J:170131
Molecular Function	GO:0005515	protein binding	IPI	J:146158
Molecular Function	GO:0016500	protein-hormone receptor activity	ISO	J:155856
Molecular Function	GO:0004888	transmembrane signaling receptor activity	TAS	J:38955
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2586548
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2586557
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2586558
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671739
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671740
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671830
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671831
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671832
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671836
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671841
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671843
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671852
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671854
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2671877
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2672295
Cellular Component	GO:0005886	plasma membrane	TAS	J:38955
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0001525	angiogenesis	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0098868	bone growth	IMP	J:60001
Biological Process	GO:0008203	cholesterol metabolic process	IGI	J:100492
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0042755	eating behavior	ISO	J:155856
Biological Process	GO:0097009	energy homeostasis	IMP	J:219525
Biological Process	GO:0097009	energy homeostasis	IMP	J:82334
Biological Process	GO:0014009	glial cell proliferation	IGI	J:252721
Biological Process	GO:0006094	gluconeogenesis	IMP	J:204007
Biological Process	GO:0042593	glucose homeostasis	IMP	J:219525
Biological Process	GO:0042593	glucose homeostasis	IMP	J:82334
Biological Process	GO:0005977	glycogen metabolic process	IGI	J:252721
Biological Process	GO:0033210	leptin-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0033210	leptin-mediated signaling pathway	IMP	J:82334
Biological Process	GO:0033210	leptin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:1903999	negative regulation of eating behavior	ISO	J:155856
Biological Process	GO:0045721	negative regulation of gluconeogenesis	IMP	J:204007
Biological Process	GO:0051346	negative regulation of hydrolase activity	IGI	J:100492
Biological Process	GO:1904060	negative regulation of locomotor rhythm	ISO	J:155856
Biological Process	GO:0006909	phagocytosis	IMP	J:115105
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:65231
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0046850	regulation of bone remodeling	IMP	J:60001
Biological Process	GO:0060259	regulation of feeding behavior	IMP	J:82334
Biological Process	GO:0019222	regulation of metabolic process	TAS	J:38955
Biological Process	GO:0051049	regulation of transport	ISO	J:164563
Biological Process	GO:0044321	response to leptin	IMP	J:82334
Biological Process	GO:0019953	sexual reproduction	IMP	J:82334
Biological Process	GO:0007165	signal transduction	TAS	J:38955
Biological Process	GO:0030217	T cell differentiation	IMP	J:49623