neural tube defect Disease Ontology Browser

Disease Ontology Browser

neural tube defect (DOID:0080074)
Alliance: disease page
Alt IDs: OMIM:301410, OMIM:601634
Definition: A physical disorder characterized by incomplete closure of the neural tube.

Term Browser
Genes (23)
Models (14)

Disease References using Mouse Models (12)

Mouse Models

Human Disease Modeled: neural tube defect

Allelic Composition	Genetic Background	Reference	Phenotypes
Pax1un/Pax1+ Tcf3tm1Cmu/Tcf3tm1Cmu	involves: 129P2/OlaHsd * C3H * C57BL/6	J:103567	View

Mouse Models

Human Disease Modeled: neural tube defect

Allelic Composition	Genetic Background	Reference	Phenotypes
Celsr1Crsh/Celsr1+ ScribCrc/Scrib+	C3H.Cg-Scrib^Crc Celsr1^Crsh	J:216413	View

Mouse Models

Human Disease Modeled: neural tube defect

Allelic Composition	Genetic Background	Reference	Phenotypes
Celsr1Scy/Celsr1+ ScribCrc/Scrib+	C3H.Cg-Scrib^Crc Celsr1^Scy	J:216413	View

Mouse Models

Human Disease Modeled: neural tube defect
Associated Mouse Gene: Mthfd1l

Allelic Composition	Genetic Background	Reference	Phenotypes
Mthfd1ltm1b(EUCOMM)Wtsi/Mthfd1ltm1b(EUCOMM)Wtsi	involves: C57BL/6N * FVB/N	J:193285	View

Mouse Models

Human Disease Modeled: neural tube defect
Associated Mouse Gene: Mthfr

Allelic Composition	Genetic Background	Reference	Phenotypes
Mthfrtm1Rzn/Mthfrtm1Rzn	involves: 129S1/Sv * 129X1/SvJ * BALB/c	J:67779	View

Mouse Models

Human Disease Modeled: neural tube defect
Associated Mouse Gene: Vangl2

Allelic Composition	Genetic Background	Reference	Phenotypes
Vangl2Lp/Vangl2Lp	involves: CBA/Ca * LPT/Le	J:47700	View
Vangl1Gt(XL802)Byg/Vangl1+ Vangl2Lp/Vangl2+	involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ	J:132697	View
ScribCrc/Scrib+ Vangl2Lp/Vangl2+	C3H.Cg-Vangl2^Lp Scrib^Crc	J:216413	View
Celsr1Crsh/Celsr1+ Vangl2Lp/Vangl2+	C3H.Cg-Vangl2^Lp Celsr1^Crsh	J:216413	View

Mouse Models

Human Disease Modeled: neural tube defect

Allelic Composition	Genetic Background	Reference	Phenotypes
Vangl1Gt(XL802)Byg/Vangl1+ Vangl2Lp/Vangl2+	involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ	J:132697	View

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg	involves: 129P2/OlaHsd * C57BL/6J	J:132697	View

Mouse Models

Human Disease Modeled: neural tube defect
Associated Mouse Gene: Lrp6

Allelic Composition	Genetic Background	Reference	Phenotypes
Lrp6Cd/Lrp6Cd	A-Lrp6^Cd	J:58433, J:101423	View

Mouse Models

Human Disease Modeled: neural tube defect
Associated Mouse Gene: Pax3

Allelic Composition	Genetic Background	Reference	Phenotypes
Pax3Sp-1Wli/Pax3Sp-1Wli	involves: C57BL/6J * CBA/CaJ	J:196572	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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