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Phenotypes Associated with This Genotype
Genotype
MGI:3574961
Allelic
Composition
Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mthfrtm1Rzn mutation (2 available); any Mthfr mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 76.4% survived past 5 weeks of age

liver/biliary system
• some microvesicular steatosis in the liver

growth/size/body
• slower development than normal

homeostasis/metabolism
• lipid accumulation in the aorta near the aortic valve but no foam cells
• some microvesicular steatosis in the liver

limbs/digits/tail
• sometimes

reproductive system
• delayed maturation of external genitalia but generally fertile

skeleton
• occasionally

vision/eye
• among other facial anomalies

nervous system
• intermingled with granule cells rather than forming a discrete layer
• as determined in sagittal sections

integument
• delayed about 5 days in appearance

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neural tube defect DOID:0080074 OMIM:301410
OMIM:601634
J:67779


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory