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Tg(Lck-cre)548Jxm
Transgene Detail
Summary
Symbol: Tg(Lck-cre)548Jxm
Name: transgene insertion 548, Jamey Marth
MGI ID: MGI:2176199
Synonyms: Lck-cre, pLck-cre, Tg(Lck-cre), TgN(Lck-cre)548Jxm
Transgene: Tg(Lck-cre)548Jxm  Location: unknown  Genetic Position: Chr11, Syntenic
Alliance: Tg(Lck-cre)548Jxm page
Lung and salivary gland inflammation in Tgfb1tm2.1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1tm1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutations:    Duplication, Insertion
 
Tg(Lck-cre)548Jxm expression driven by 1 gene
 
Mutation detailsThis transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the mouse lck promoter, active in the T cell lineage. Transgene insertion occurred on Chr11, causing a 1 bp duplication. (J:67674)
Recombinase
activity
Activity:
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Driver: Lck (mouse)
Summary of all recombinase alleles driven by Lck.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(Lck-cre)548Jxm
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Homozygous transgenic mice are viable and have no major defects.
References
Original:  J:67674 Hennet T, et al., T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12070-4
All:  208 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory