Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mtnr1atm1Rep
Name:	melatonin receptor 1A; targeted mutation 1, Steven M Reppert
MGI ID:	MGI:2450160
Synonyms:	MT1-, MT1 KO
Gene:	Mtnr1a  Location: Chr8:45522174-45541543 bp, + strand  Genetic Position: Chr8, 24.95 cM
Alliance:	Mtnr1atm1Rep page

Germline Transmission:	Earliest citation of germline transmission: J:41859
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the 5' untranslated region and the first cytoplasmic loop. Autoradiography showed an absence of melatonin binding in sections of homozygous mutant brains, indicating complete functional ablation. (J:41859)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mtnr1a Mutation:	24 strains or lines available

Original:	J:41859 Liu C, et al., Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron. 1997 Jul;19(1):91-102
All:	29 reference(s)