Analysis Tools
vision/eye
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• number of cells in the ganglion cell layer is reduced at 18 months of age, but not at 3 or 12 months of age
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• at 18 months of age
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• at 18 months of age
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• a reduction in the number of photoreceptor cells in the outer nuclear layer is seen at 12 months, but not 3 months, of age
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• amplitudes of the a- and b-wave are not greater at midnight than at midday as in controls indicating that the diurnal rhythm in the dark-adapted ERG response is absent
• melatonin injection during the day or middle of the night does not produce any changes in the ERG of dark-adapted mutants as in controls which show increased a- and b-wave amplitudes in response to melatonin and does not affect the scotopic response threshold
• melatonin injection has no effect on b-wave amplitude in light-adapted ERG responses to flashes of light recorded after 1 hour of dark adaptation compared to controls which show an increase in b-wave amplitude
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• dark-adapted ERG a-wave amplitudes are decreased
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• dark-adapted ERG b-wave amplitudes are decreased
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nervous system
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• number of cells in the ganglion cell layer is reduced at 18 months of age, but not at 3 or 12 months of age
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• at 18 months of age
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• at 18 months of age
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• a reduction in the number of photoreceptor cells in the outer nuclear layer is seen at 12 months, but not 3 months, of age
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