Phenotypes for Gt(ROSA)26Sor Rbpms Rbpms2 Tg(Myh6-cre)2182Mds MGI:8226709 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm11(CAG-tdTomato*,-GFP*)Nat} mutation (1 available); any Gt(ROSA)26Sor mutation (1243 available)
Rbpms2^tm2.1Thbr mutation (0 available); any Rbpms2 mutation (204 available)
Rbpms^tm1.1Thbr mutation (0 available); any Rbpms mutation (493 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:369747 )

• at E16.5 the nuclei are irregular in outline and size or associated with micronuclei

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

muscle

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

cellular

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

abnormal cell nucleus morphology ( J:369747 )

• at E16.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

increased micronucleus incidence ( J:369747 )

• at E16.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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