Phenotypes Associated with This Genotype

Genotype
MGI:8226672

• Allelic Composition: Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr; Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial trabeculae morphology ( J:369747 )

• slight disorganization of the layer

thin ventricle myocardium compact layer ( J:369747 )

• reduced thickness in the ventricles and septum at E16.5 and E18.5

• however, the thickness of the trabecular layer is not altered

abnormal fetal cardiomyocyte morphology ( J:369747 )

• disruption of sarcomere integrity in cardiomyocytes at E16.5

• nuclear abnormalities

abnormal fetal cardiomyocyte physiology ( J:369747 )

• expression analysis indicates defects in cardiomyocyte-specific alternative splicing

muscle

abnormal myocardial trabeculae morphology ( J:369747 )

• slight disorganization of the layer

thin ventricle myocardium compact layer ( J:369747 )

• reduced thickness in the ventricles and septum at E16.5 and E18.5

• however, the thickness of the trabecular layer is not altered

abnormal sarcomere morphology ( J:369747 )

• disruption of sarcomere integrity in cardiomyocytes at E16.5

cellular

abnormal sarcomere morphology ( J:369747 )

• disruption of sarcomere integrity in cardiomyocytes at E16.5