Phenotypes Associated with This Genotype

Genotype
MGI:7764516

• Allelic Composition: Abl1^tm1Ajk/Abl1^tm1Ajk; Tg(Nes-cre)1Kag/0; Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:327648 )

N • mice injected with an adenovirus expressing tTA into the ventral midbrain and then treated with doxycycline show rescue of the nigral degeneration of dopamine neurons and loss of dopamine seen in single Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0 mice

N • mice injected with an adenovirus expressing tTA into the ventral midbrain show prevention of the amphetamine-induced rotation, indicating that the dopamine neurons are functionally spared