Tg(tetO/Prnp-SNCA*A53T)4360Tmd
Transgene Detail

Summary

• Symbol: Tg(tetO/Prnp-SNCA*A53T)4360Tmd
• Name: transgene insertion 4360, Ted M Dawson
• MGI ID: MGI:7428915
• Synonyms: TetP-hA53T alpha-syn
• Transgene: Tg(tetO/Prnp-SNCA*A53T)4360Tmd Location: unknown
• Alliance: Tg(tetO/Prnp-SNCA*A53T)4360Tmd page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO/Prnp-SNCA*A53T)4360Tmd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  Transgene codes for a protein with an alanine to threonine mutation.

• Mutation details: The transgenic construct contains the tet promoter (tetO) and mouse prion protein non-coding exons 1-2 upstream of the human SNCA cDNA containing the A53T mutation, followed by mouse prion protein non-coding exon 3. Three lines with high copy number were generated (hA53T-4360, hA53T-4299, hA53T-4454). This is the highest expressing line. (J:327648)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:327648 Brahmachari S, et al., Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain. 2019 Aug 1;142(8):2380-2401
• All: 1 reference(s)