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Phenotypes Associated with This Genotype
Genotype
MGI:7716851
Allelic
Composition
Smyd5tm1a(EUCOMM)Wtsi/Smyd5tm1a(EUCOMM)Wtsi
Tg(Vil1-cre)997Gum/0
Genetic
Background
B6.Cg-Smyd5tm1a(EUCOMM)Wtsi Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smyd5tm1a(EUCOMM)Wtsi mutation (1 available); any Smyd5 mutation (33 available)
Tg(Vil1-cre)997Gum mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit protection from dextran sulfate sodium (DSS)-induced colitis, with mice losing less weight than controls, better-shaped stools and less rectal bleeding, less colon shortening, less extensive ulceration and erosion, less severe inflammatory cell infiltration, less thickening of mucosa, and improved epithelial barrier integrity

digestive/alimentary system
• mice show a slight, but significant, increase in the number of mitochondria in intestinal epithelial cells
• however, mitochondrial perimeter and circularity in intestinal epithelial cells do not show any differences
• however, mice show no other abnormalities in the gastrointestinal tract under basal conditions
• mice exhibit protection from dextran sulfate sodium (DSS)-induced colitis, with mice losing less weight than controls, better-shaped stools and less rectal bleeding, less colon shortening, less extensive ulceration and erosion, less severe inflammatory cell infiltration, less thickening of mucosa, and improved epithelial barrier integrity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory