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Targeted Allele Detail
Symbol: Smyd5tm1a(EUCOMM)Wtsi
Name: SET and MYND domain containing 5; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431696
Gene: Smyd5  Location: Chr6:85408971-85423417 bp, + strand  Genetic Position: Chr6, 37.44 cM
Alliance: Smyd5tm1a(EUCOMM)Wtsi page
IMPC: Smyd5 gene page
Mutant Cell Lines:  EPD0027_5_A02, EPD0027_5_A03, EPD0027_5_B01, EPD0027_5_B02, EPD0027_5_B03, EPD0027_5_C01, EPD0027_5_C02, EPD0027_5_D02, EPD0027_5_E02, EPD0027_5_E03, EPD0027_5_F01, EPD0027_5_G01, EPD0027_5_G02, EPD0027_5_G03, EPD0027_5_H01, EPD0027_5_H02, EPD0027_5_H03
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
Mutation detailsThe L1L2_gt0 cassette was inserted at position 85437617 of Chromosome 6 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 85438499. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Smyd5 Mutation:  25 strains or lines available
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory