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Phenotypes Associated with This Genotype
Genotype
MGI:7711290
Allelic
Composition		 Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Zdhhc20em1Jdo/Zdhhc20em1Jdo
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2Tyj mutation (2 available); any Trp53 mutation (237 available)
Zdhhc20em1Jdo mutation (1 available); any Zdhhc20 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:348743 )
N
• survival is similar to mutant mice wild-type for Zdhhc20

neoplasm
decreased metastatic potential ( J:348743 )
• liver metastases are found in 40% of mice compared to 93% of mutant mice wild-type for Zdhhc20
• a similar trend is seen for lung metastases
• both total liver lesion area and number are profoundly reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory