Phenotypes Associated with This Genotype

Genotype
MGI:7625702

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Orai1^tm1Smua/Orai1^tm1Smua; Orai3^em1.1Treb/Orai3^em1.1Treb
• Genetic Background: involves: BALB/c * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:345485 )

N • immune responses to influenza A infection are similar to controls

abnormal B cell physiology ( J:345485 )

• store-operated Ca2+ entry in B cells is reduced by~83%

• anti-IgM mediated NFAT1 translocation is significantly reduced

abnormal B cell activation ( J:345485 )

• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted

decreased B cell proliferation ( J:345485 )

• decrease in both proliferation and viablity of cells following anti-IgM stimulation

hematopoietic system

abnormal B cell physiology ( J:345485 )

• store-operated Ca2+ entry in B cells is reduced by~83%

• anti-IgM mediated NFAT1 translocation is significantly reduced

abnormal B cell activation ( J:345485 )

• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted

decreased B cell proliferation ( J:345485 )

• decrease in both proliferation and viablity of cells following anti-IgM stimulation

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:345485 )

• store-operated Ca2+ entry in B cells is reduced by~83%

cellular

decreased B cell proliferation ( J:345485 )

• decrease in both proliferation and viablity of cells following anti-IgM stimulation