Phenotypes Associated with This Genotype

Genotype
MGI:7625698

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Orai1^tm1Smua/Orai1^tm1Smua
• Genetic Background: involves: BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:345485 )

N • no defects in B cell development in the bone marrow or spleen

abnormal B cell physiology ( J:345485 )

• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%

• however, agonist induced Ca2+ oscillations are similar to controls

• residual SOCE activity is not inhibited by 2-aminoethyl diphenyl borate (2-APB)

• anti-IgM mediated NFAT1 translocation is significantly reduced

abnormal B cell activation ( J:345485 )

• following anti-IgM stimulation proliferation is similar to controls but cell viability is moderately reduced

• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:345485 )

• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%

• residual SOCE activity in B cells is not inhibited by 2-aminoethyl diphenyl borate (2-APB)

• however, agonist induced Ca2+ oscillations in B cells are similar to controls

hematopoietic system

abnormal B cell physiology ( J:345485 )

• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%

• however, agonist induced Ca2+ oscillations are similar to controls

• residual SOCE activity is not inhibited by 2-aminoethyl diphenyl borate (2-APB)

• anti-IgM mediated NFAT1 translocation is significantly reduced

abnormal B cell activation ( J:345485 )

• following anti-IgM stimulation proliferation is similar to controls but cell viability is moderately reduced

• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted