Phenotypes Associated with This Genotype

Genotype
MGI:7564089

• Allelic Composition: Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi}; Tcrd^tm1Mom/Tcrd^tm1Mom; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

digestive/alimentary system

increased small intestinal crypt cell apoptosis ( J:340266 )

abnormal Paneth cell morphology ( J:340266 )

• remaining Paneth cells display abnormal lysozyme staining patterns

decreased Paneth cell number ( J:340266 )

• spontaneous Paneth cell loss in the absence of infection with murine norovirus

• however, goblet cell numbers are similar to controls

decreased small intestinal villus height ( J:340266 )

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

homeostasis/metabolism

abnormal cytokine level ( J:340266 )

• increased local levels of cytokine production in the small intestine

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

abnormal cytokine level ( J:340266 )

• increased local levels of cytokine production in the small intestine

cellular

increased small intestinal crypt cell apoptosis ( J:340266 )

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:340266 )

• remaining Paneth cells display abnormal lysozyme staining patterns

decreased Paneth cell number ( J:340266 )

• spontaneous Paneth cell loss in the absence of infection with murine norovirus

• however, goblet cell numbers are similar to controls