Analysis Tools
mortality/aging
cellular
|
• embryonic mice show a reduction of neurogenesis in the brain associated with a defective cell cycle of intermediate neural progenitors, which stall at the S and G2/M phases
|
embryo
|
• mice show defects in neural tube closure, with severely reduced or absent tail buds
|
|
• mice exhibit severely reduced or absent tail buds
• dams administered the Wnt agonist CHIR99021 intraperitoneally twice daily starting at E4.5 and until E12.5, show partial rescue of tail growth, with about 25% off embryos showing a diminutive tail
|
limbs/digits/tail
|
• mice exhibit severely reduced or absent tail buds
• dams administered the Wnt agonist CHIR99021 intraperitoneally twice daily starting at E4.5 and until E12.5, show partial rescue of tail growth, with about 25% off embryos showing a diminutive tail
|
nervous system
|
• mice show severely defective hippocampal dentate gyrus
|
|
• mice show cobblestone-like penetration of neurons through the disrupted pial basement membrane
|
|
• embryonic mice show a reduction of neurogenesis in the brain associated with a defective cell cycle of intermediate neural progenitors, which stall at the S and G2/M phases
|
|
• mice show defects in neural tube closure, with severely reduced or absent tail buds
|
|
• mice show decreased number of cortical neurons
|
renal/urinary system
|
• cystic medullary hydronephrosis
|
skeleton
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Zaki syndrome | DOID:0070473 |
OMIM:619648 |
J:341542 | |
