Phenotypes Associated with This Genotype

Genotype
MGI:7486120

• Allelic Composition: Prmt1^{tm1a(EUCOMM)Wtsi}/Prmt1^{tm1a(EUCOMM)Wtsi}; Rb1^tm3Tyj/Rb1^tm3Tyj; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased tumor-free survival time ( J:245660 )

• median tumor-free survival is significantly increased relative to mutant mice that are either homozygotes for the wild-type Prmt1 allele or heterozygotes with one wild-type and one floxed Prmt1 allele

neoplasm

decreased osteosarcoma incidence ( J:245660 )

• microPET/CT imaging suggested a reduction in the presence of osteosarcomas at 100 days of age

• osteosarcoma tumors retain residual PRMT1 protein expression and a nonexcised Prmt1 allele

increased tumor latency ( J:245660 )

• osteosarcoma initiation is delayed relative to mutant mice that are either homozygotes for the wild-type Prmt1 allele or heterozygotes with one wild-type and one floxed Prmt1 allele

skeleton

decreased osteosarcoma incidence ( J:245660 )

• microPET/CT imaging suggested a reduction in the presence of osteosarcomas at 100 days of age

• osteosarcoma tumors retain residual PRMT1 protein expression and a nonexcised Prmt1 allele