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Phenotypes Associated with This Genotype
Genotype
MGI:7484195
Allelic
Composition		 Rb1tm3Tyj/Rb1+
Sox2tm4.1Skn/Sox2tm4.1Skn
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129 * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (12 available); any Rb1 mutation (116 available)
Sox2tm4.1Skn mutation (1 available); any Sox2 mutation (56 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased tumor-free survival time ( J:318885 )
• tumor free survival time is increased compared to mutant mice wild-type for Sox2

neoplasm
decreased osteosarcoma incidence ( J:318885 )
• compared to mutant mice wild-type for Sox2
• tumors are uniformly Sox2 positive

skeleton
decreased osteosarcoma incidence ( J:318885 )
• compared to mutant mice wild-type for Sox2
• tumors are uniformly Sox2 positive

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory