Phenotypes for Rb1 Tg(BGLAP-cre)1Clem Trp53 MGI:7482566 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(BGLAP-cre)1Clem/0
Genetic Background	involves: 129 * 129P2/OlaHsd * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm2Brn mutation (2 available); any Rb1 mutation (116 available)
Tg(BGLAP-cre)1Clem mutation (3 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:326989 )

• tumor-free survival is 146.5 days

neoplasm

increased osteosarcoma incidence ( J:326989 )

• 52.4% incidence

skeleton

increased osteosarcoma incidence ( J:326989 )

• 52.4% incidence

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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