Phenotypes Associated with This Genotype

Genotype
MGI:7443114

• Allelic Composition: Cap1^tm1.1Mbrst/Cap1^tm1.1Mbrst; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:333563 )

nervous system

impaired neuron differentiation ( J:333563 )

• less fiber tracks in the cortical intermediate zone or in the striatum than in wild-type mice

• impaired neuron differentiation in a cellular system

• impaired growth cone morphology and motility

abnormal hippocampus morphology ( J:333563 )

• determined by Nissl-staining

• however, the cerebral cortex is normal at E18.5

abnormal Ammon gyrus morphology ( J:333563 )

• reduced length

abnormal neurite morphology ( J:333563 )

• reduced length and increased width

• however, neurite numbers and branching are normal

cellular

impaired neuron differentiation ( J:333563 )

• less fiber tracks in the cortical intermediate zone or in the striatum than in wild-type mice

• impaired neuron differentiation in a cellular system

• impaired growth cone morphology and motility