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Phenotypes Associated with This Genotype
Genotype
MGI:7437607
Allelic
Composition		 Ightm1.1(Rr361-HBB)Aak/Ightm1.1(Rr361-HBB)Aak
Genetic
Background		 129.129S2(Cg)-Ightm1.1(Rr361-HBB)Aak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1.1(Rr361-HBB)Aak mutation (0 available); any Igh mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:333279 )
• reduced switching to Ighg2b in LPS-stimulated splenic B cells
• reduced switching to Ighg1 and Ighe in IL4-stimulated splenic B cells
• reduced switching to Ighg2a in IFNG-stimulated splenic B cells
• reduced switching to Igha in TGFB-stimulated splenic B cells
• normal switching to Ighg2b in TGFB-stimulated splenic B cells
• normal switching to Ighg3 in LPS-stimulated splenic B cells
decreased IgA level ( J:333279 )
• reduced expression of Igha in TGFB-stimulated splenic B cells
decreased IgE level ( J:333279 )
• reduced expression of Ighe in IL4-stimulated splenic B cells
decreased IgG1 level ( J:333279 )
• reduced expression of Ighg1 in IL4-stimulated splenic B cells
decreased IgG2a level ( J:333279 )
• reduced expression of Ighg2a in IFNG-stimulated splenic B cells
decreased IgG2b level ( J:333279 )
• reduced expression of Ighg2b in LPS-stimulated splenic B cells
• normal expression of Ighg2b in TGFB-stimulated splenic B cells

immune system
abnormal class switch recombination ( J:333279 )
• reduced switching to Ighg2b in LPS-stimulated splenic B cells
• reduced switching to Ighg1 and Ighe in IL4-stimulated splenic B cells
• reduced switching to Ighg2a in IFNG-stimulated splenic B cells
• reduced switching to Igha in TGFB-stimulated splenic B cells
• normal switching to Ighg2b in TGFB-stimulated splenic B cells
• normal switching to Ighg3 in LPS-stimulated splenic B cells
decreased IgA level ( J:333279 )
• reduced expression of Igha in TGFB-stimulated splenic B cells
decreased IgE level ( J:333279 )
• reduced expression of Ighe in IL4-stimulated splenic B cells
decreased IgG1 level ( J:333279 )
• reduced expression of Ighg1 in IL4-stimulated splenic B cells
decreased IgG2a level ( J:333279 )
• reduced expression of Ighg2a in IFNG-stimulated splenic B cells
decreased IgG2b level ( J:333279 )
• reduced expression of Ighg2b in LPS-stimulated splenic B cells
• normal expression of Ighg2b in TGFB-stimulated splenic B cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory