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Phenotypes Associated with This Genotype
Genotype
MGI:7435431
Allelic
Composition		 Krastm4Tyj/Kras+
Tg(Cdh5-cre/ERT2)1Rha/0
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6NCrl * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (8 available); any Gt(ROSA)26Sor mutation (1062 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:312482 )
• mice administered tamoxifen at P1 show early lethality beginning at P12

cardiovascular system
cardiovascular system phenotype ( J:312482 )
N
• mice administered tamoxifen at P1fail to show frequent cranial hemorrhage or cortical brain arteriovenous malformations (bAVMs) at P14 or P21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory