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Phenotypes Associated with This Genotype
Genotype
MGI:7380247
Allelic
Composition		 Rtl5em1Tmki/Rtl5em1Tmki
Rtl6tm2.1Tmki/Rtl6tm2.1Tmki
Genetic
Background		 involves: C57BL/6NCrlj * C57BL/6NSlc * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtl5em1Tmki mutation (1 available); any Rtl5 mutation (4 available)
Rtl6tm2.1Tmki mutation (1 available); any Rtl6 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:329352 )
• greatly reduced dsRNA analog removal
• however, injected dsRNA removal activity was unaffected
decreased susceptibility to endotoxin shock ( J:329352 )
• LPS remains in the extracellular space even after 2 h unlike in brains of wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory