Phenotypes Associated with This Genotype

Genotype
MGI:7344038

• Allelic Composition: Men1^tm1.2Ctre/Men1^tm1.2Ctre; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:127545 )

• all pups die by P1

behavior/neurological

absent gastric milk in neonates ( J:127545 )

craniofacial

abnormal basisphenoid bone morphology ( J:127545 )

abnormal pterygoid process morphology ( J:127545 )

abnormal palatal shelf bone ossification ( J:127545 )

• skeletal staining revealed the absence of ossified palatal shelves

palatal shelves fail to meet at midline ( J:127545 )

• newborns exhibit unfused palatal shelves

cleft secondary palate ( J:127545 )

• all newborns exhibit a bilateral cleft of the secondary palate

bilateral cleft palate ( J:127545 )

skeleton

skeleton phenotype ( J:127545 )

N • newborn pups do NOT exhibit rib or sternum defects

abnormal basisphenoid bone morphology ( J:127545 )

abnormal pterygoid process morphology ( J:127545 )

abnormal palatal shelf bone ossification ( J:127545 )

• skeletal staining revealed the absence of ossified palatal shelves

digestive/alimentary system

abnormal palatal shelf bone ossification ( J:127545 )

• skeletal staining revealed the absence of ossified palatal shelves

palatal shelves fail to meet at midline ( J:127545 )

• newborns exhibit unfused palatal shelves

cleft secondary palate ( J:127545 )

• all newborns exhibit a bilateral cleft of the secondary palate

bilateral cleft palate ( J:127545 )

growth/size/body

abnormal palatal shelf bone ossification ( J:127545 )

• skeletal staining revealed the absence of ossified palatal shelves

palatal shelves fail to meet at midline ( J:127545 )

• newborns exhibit unfused palatal shelves

cleft secondary palate ( J:127545 )

• all newborns exhibit a bilateral cleft of the secondary palate

bilateral cleft palate ( J:127545 )