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Phenotypes Associated with This Genotype
Genotype
MGI:7333176
Allelic
Composition		 Kdm6atm1c(EUCOMM)Wtsi/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294895 )
• partially penetrant
cleft hard palate ( J:294895 )
• in some cases the palatine bone fails to fuse at the midline

embryo
abnormal cranial neural crest cell morphology ( J:294895 )
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation

digestive/alimentary system
cleft palate ( J:294895 )
• partially penetrant
cleft hard palate ( J:294895 )
• in some cases the palatine bone fails to fuse at the midline

nervous system
abnormal cranial neural crest cell morphology ( J:294895 )
• neural crest cells in the supraorbital arch have a laterally shifted pattern of osteoblast and chondrocyte differentiation

growth/size/body
cleft palate ( J:294895 )
• partially penetrant
cleft hard palate ( J:294895 )
• in some cases the palatine bone fails to fuse at the midline

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory