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Phenotypes Associated with This Genotype
Genotype
MGI:7281832
Allelic
Composition
Adarem1Stsn/Adartm1Olds
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarem1Stsn mutation (0 available); any Adar mutation (58 available)
Adartm1Olds mutation (0 available); any Adar mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at weaning

hematopoietic system
• lymphoid depletion

homeostasis/metabolism
• increased expression of interferon-stimulated genes in cerebellum, kidney and liver
• increased expression of integrated stress response (ISR) genes in kidney and liver
• normal expression of integrated stress response (ISR) genes in cerebellum

immune system
• lymphoid depletion

liver/biliary system
• extensive microvesicular cytoplasmic vacuolation

mortality/aging
• no survival beyond ~130 days

renal/urinary system
• significant immunoglobulin G (IgG) deposition
• increasing with age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory