Phenotypes Associated with This Genotype

Genotype
MGI:7281482

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Myd88^em1.1Rsky/Myd88⁺
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:308792 )

N • normal B cell development in bone marrow

N • normal Ig class switching in B cells in spleen, mesenteric lymph nodes and Peyers patches

enlarged spleen ( J:308792 )

• from age 30 weeks

increased germinal center B cell number ( J:308792 )

• increased frequency and number from age 30 weeks, increasing over time

increased plasma cell number ( J:308792 )

• increased number of IgM+ plasma cells

• increased plasma cell compartment in spleen and bone marrow

• increased frequency and number of TACI+ CD138+ plasma cells from age 50 weeks

abnormal splenic cell ratio ( J:308792 )

• increased frequency and number of germinal center B cells from age 30 weeks, increasing over time

• normal frequency of follicular and marginal zone B cells

increased IgM level ( J:308792 )

• increased serum levels from age 10 weeks, increasing over time

immune system

enlarged spleen ( J:308792 )

• from age 30 weeks

increased germinal center B cell number ( J:308792 )

• increased frequency and number from age 30 weeks, increasing over time

increased plasma cell number ( J:308792 )

• increased number of IgM+ plasma cells

• increased plasma cell compartment in spleen and bone marrow

• increased frequency and number of TACI+ CD138+ plasma cells from age 50 weeks

abnormal splenic cell ratio ( J:308792 )

• increased frequency and number of germinal center B cells from age 30 weeks, increasing over time

• normal frequency of follicular and marginal zone B cells

increased IgM level ( J:308792 )

• increased serum levels from age 10 weeks, increasing over time

growth/size/body

enlarged spleen ( J:308792 )

• from age 30 weeks