Phenotypes Associated with This Genotype

Genotype
MGI:7277828

• Allelic Composition: Pten^tm2.1Ppp/Pten^tm2.1Ppp; Rb1^tm2Brn/Rb1^tm2Brn; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:307910 )

• median survival time of 38 weeks

• castrated mice have a median survival time of 43.5 weeks

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:307910 )

• prostates from 8-week-old mice are composed of androgen receptor-positive, high-grade prostatic intraepithelial neoplasia lesions

• tumors regress post-castration but resume growth 24 weeks post-castration

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:307910 )

• prostates from 8-week-old mice are composed of androgen receptor-positive, high-grade prostatic intraepithelial neoplasia lesions

• tumors regress post-castration but resume growth 24 weeks post-castration

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:307910 )

• prostates from 8-week-old mice are composed of androgen receptor-positive, high-grade prostatic intraepithelial neoplasia lesions

• tumors regress post-castration but resume growth 24 weeks post-castration