Phenotypes for Gt(ROSA)26Sor Taf1b Trp53 MGI:6887493 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Taf1b^{tm1c(EUCOMM)Hmgu}/Taf1b^{tm1c(EUCOMM)Hmgu} Trp53^tm1Tyj/Trp53^tm1Tyj Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * C57BL/6N
Cell Lines	HEPD0596_3_G02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (3 available); any Gt(ROSA)26Sor mutation (1062 available)
Taf1b^{tm1c(EUCOMM)Hmgu} mutation (1 available); any Taf1b mutation (34 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal nucleolus morphology ( J:321558 )

• tamoxifen treated MEFs exhibit disruption of nucleolar structure characteristic of nucleolar stress

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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