Phenotypes for Fanci MGI:6827421 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fanci^em2Szh/Fanci^em2Szh
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanci^em2Szh mutation (0 available); any Fanci mutation (200 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased male germ cell number ( J:312543 )

• at 8 weeks and more severe at 12 months

oligozoospermia ( J:312543 )

increased male germ cell apoptosis ( J:312543 )

• despite normal meiotic progression and meiotic recombination

abnormal DNA methylation during gametogenesis ( J:312543 )

• increased accumulation of H3K9me3 on sex chromosomes

seminiferous tubule degeneration ( J:312543 )

• with massive cell loss

small testis ( J:312543 )

decreased testis weight ( J:312543 )

female infertility ( J:312543 )

male infertility ( J:312543 )

endocrine/exocrine glands

seminiferous tubule degeneration ( J:312543 )

• with massive cell loss

small testis ( J:312543 )

decreased testis weight ( J:312543 )

cellular

decreased male germ cell number ( J:312543 )

• at 8 weeks and more severe at 12 months

oligozoospermia ( J:312543 )

increased male germ cell apoptosis ( J:312543 )

• despite normal meiotic progression and meiotic recombination

abnormal DNA methylation during gametogenesis ( J:312543 )

• increased accumulation of H3K9me3 on sex chromosomes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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