Phenotypes Associated with This Genotype

Genotype
MGI:6798088

• Allelic Composition: Tg(LRRK2*G2019S)2AMjff/0
• Genetic Background: C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain interneuron morphology ( J:312767 )

• loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum that is more severe than in Lrrk2^tm4.1Arte homozygotes

• fewer and shorter cilia on striatal astrocytes

• however, cilia on surrounding neurons are normal

abnormal dorsal striatum morphology ( J:312767 )

• loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum that is more severe than in Lrrk2^tm4.1Arte homozygotes

• fewer and shorter cilia on striatal astrocytes

• however, cilia on surrounding neurons are normal