Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrrk2tm4.1Arte
Name:	leucine-rich repeat kinase 2; targeted mutation 4.1, TaconicArtemis
MGI ID:	MGI:6273209
Synonyms:	G2019S-LRRK2
Gene:	Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance:	Lrrk2tm4.1Arte page

Germline Transmission:	Earliest citation of germline transmission: J:268603
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, Humanized sequence) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A proximal loxP site and FRT-flanked PGK-neomycin cassette were inserted in intron 41, a distal loxP site was inserted in intron 42, and G2019S mutation was inserted in exon 41 via homologous recombination. Flp mediated recombination removed the neo cassette. The expressed protein is resilient to kinase inhibition. (J:147112, J:268603)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:	156 strains or lines available

Original:	J:268603 Kelly K, et al., The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition. Exp Neurol. 2018 Nov;309:1-13
All:	7 reference(s)