Phenotypes Associated with This Genotype

Genotype
MGI:6781800

• Allelic Composition: Rnf40^tm1.1Sajo/Rnf40^tm1.1Sajo; Tg(Car1-cre)5Flt/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased susceptibility to induced colitis ( J:311838 )

• mice treated with DSS to induce colorectal inflammation and acute colitis show a lower disease activity index compared to control mice, with minimal weight loss and unaffected stool consistency and frequency of occult blood and only mild epithelial damage in the colon

• DSS-treated mice show only low proportions of epithelium with medium to severe signs of inflammation indicating reduced colorectal inflammation

immune system

decreased susceptibility to induced colitis ( J:311838 )

• mice treated with DSS to induce colorectal inflammation and acute colitis show a lower disease activity index compared to control mice, with minimal weight loss and unaffected stool consistency and frequency of occult blood and only mild epithelial damage in the colon

• DSS-treated mice show only low proportions of epithelium with medium to severe signs of inflammation indicating reduced colorectal inflammation

skeleton

increased bone strength ( J:311838 )

• the applied strength when bone deformation is induced (yield load) and before (failure load) and during (Fmax) breaking the bone is higher, indicating that mice have less fragile bones