Phenotypes Associated with This Genotype

Genotype
MGI:6739868

• Allelic Composition: Ppdpf^tm1Nju/Ppdpf^tm1Nju; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:307283 )

• mice exhibit a higher body weight than wild-type mice at 8 months of age

increased liver weight ( J:307283 )

• livers are heavier at 8 months of age

• mice fed a high-fat diet exhibit a greater increase in liver weight than wild-type mice

homeostasis/metabolism

increased circulating free fatty acids level ( J:307283 )

• nonesterified fatty acid (NEFA) levels are increased

• mice fed a high-fat diet exhibit a greater increase in NEFA levels than wild-type mice

increased circulating triglyceride level ( J:307283 )

• serum triglycerides are increased

• mice fed a high-fat diet show a greater increase in serum triglyceride levels than wild-type mice

impaired glucose tolerance ( J:307283 )

• mice develop more severe glucose intolerance than wild-type mice after 16 weeks of a high-fat diet

insulin resistance ( J:307283 )

• mice develop more severe insulin resistance than wild-type mice after 16 weeks of a high-fat diet

increased liver triglyceride level ( J:307283 )

• liver triglyceride levels are increased

• mice fed a high-fat diet show a greater increase in liver triglyceride levels than wild-type mice

increased lipogenesis ( J:307283 )

• primary hepatocytes treated with palmitic acid to induce steatosis in vitro show a greater increase in lipid deposition than in wild-type hepatocytes

• hepatocytes treated with mTOR inhibitor Torin1 show reduced lipid deposition

liver/biliary system

increased liver weight ( J:307283 )

• livers are heavier at 8 months of age

• mice fed a high-fat diet exhibit a greater increase in liver weight than wild-type mice

increased liver triglyceride level ( J:307283 )

• liver triglyceride levels are increased

• mice fed a high-fat diet show a greater increase in liver triglyceride levels than wild-type mice

hepatic steatosis ( J:307283 )

• mice develop fatty liver disease, with livers showing lipid droplets with increased size and serious steatosis at 8 months of age

• mice treated with the mTOR inhibitor Rapamycin show reduced body weight, liver weight, liver triglyceride, liver NEFA, inhibition of lipid droplet formation

increased susceptibility to diet-induced hepatic steatosis ( J:307283 )

• mice exhibit increased susceptibility to high-fat diet-induced non-alcoholic fatty liver disease, with mice showing a greater increase in liver weight, liver triglyceride and NEFA content, more serious steatosis and higher serum triglyceride levels, develop more severe glucose intolerance and insulin resistance, and have larger and more lipid droplets in the livers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
metabolic dysfunction-associated steatotic liver disease		DOID:0080208	OMIM:613282 OMIM:613387	J:307283