Phenotypes Associated with This Genotype

Genotype
MGI:6723730

• Allelic Composition: Amotl1^tm1Laho/Amotl1^tm1Laho; Tg(Cdh5-cre/ERT2)1Rha/0; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal tumor vascularization ( J:253854 )

• mice injected with tamoxifen show significantly enlarged and dilated infiltrating blood vessels in the mammary tumor area relative to control mice, as determined by vessel diameter

• however, adult retinal vessels from these mice exhibit no changes in vessel diameter

neoplasm

abnormal tumor vascularization ( J:253854 )

• mice injected with tamoxifen show significantly enlarged and dilated infiltrating blood vessels in the mammary tumor area relative to control mice, as determined by vessel diameter

• however, adult retinal vessels from these mice exhibit no changes in vessel diameter

increased tumor latency ( J:253854 )

• mice injected with tamoxifen exhibit a longer lag time until mammary gland tumors are detected relative to control mice

• however, overall tumor progression is not affected