Analysis Tools
cardiovascular system
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• pups injected with tamoxifen at P1-P3 show a decreased density of the vessel network covering a smaller area of the retina at P6; the vascular density and number of branching points are significantly lower in the periphery and center of P6 retinas
• however, mice injected with tamoxifen at an adult stage show no alterations in the number of branching points and vascular density in adult retinas
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• pups injected with tamoxifen at P1-P3 show a small but significant reduction in the number of tip cells per vessel length and abnormal pericyte morphology resulting in decreased pericyte coverage of blood vessels in P6 retinas
• however, the number of filopodia per tip cell is relatively normal at P6
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• pups injected with tamoxifen at P1-P3 show abnormal pericyte morphology, with mural cells "bulging out" from blood vessels, in P6 retinas
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vision/eye
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• pups injected with tamoxifen at P1-P3 show a decreased density of the vessel network covering a smaller area of the retina at P6; the vascular density and number of branching points are significantly lower in the periphery and center of P6 retinas
• however, mice injected with tamoxifen at an adult stage show no alterations in the number of branching points and vascular density in adult retinas
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• pups injected with tamoxifen at P1-P3 show a small but significant reduction in the number of tip cells per vessel length and abnormal pericyte morphology resulting in decreased pericyte coverage of blood vessels in P6 retinas
• however, the number of filopodia per tip cell is relatively normal at P6
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