Phenotypes Associated with This Genotype

Genotype
MGI:6712273

• Allelic Composition: Gpr182^{tm2c(KOMP)Wtsi}/Gpr182^{tm2c(KOMP)Wtsi}; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: B6.Cg-Gpr182^{tm2c(KOMP)Wtsi} Tg(Cdh5-cre/ERT2)1Rha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:305796 )

• mice show an increase in colony-forming units of hematopoietic stem/progenitors in the peripheral blood and in the spleen, paralleled by an increase in c-Kit+ cells in the spleen, following tamoxifen treatment

increased neutrophil cell number ( J:305796 )

• mice show increased levels of neutrophils and monocytes in peripheral blood following induction with tamoxifen

increased monocyte cell number ( J:305796 )

• mice show increased levels of neutrophils and monocytes in peripheral blood following induction with tamoxifen

decreased hematopoietic stem cell number ( J:305796 )

• mice show a decrease in long-term repopulating hematopoietic stem cells (LT-HSCs; CD150+CD48-CD34low LSK) in the bone marrow following induction with tamoxifen

• however, progenitor populations are not affected

homeostasis/metabolism

abnormal circulating chemokine level ( J:305796 )

• mice induced with tamoxifen show a rapid increase in plasma concentration of CXCL10, CXCL12, and CXCL13, with increase of CXCL13 more pronounced than the other two

• levels of CXCL12 and CXCL10 remain stable over a period of 20 days while CXCL13 levels continue to increase after induction

• however, no alteration in the distribution of CXCL12 is seen in the bone marrow

increased circulating CXCL10 level ( J:305796 )

• plasma concentration of CXCL10 is increased following tamoxifen treatment

immune system

increased neutrophil cell number ( J:305796 )

• mice show increased levels of neutrophils and monocytes in peripheral blood following induction with tamoxifen

increased monocyte cell number ( J:305796 )

• mice show increased levels of neutrophils and monocytes in peripheral blood following induction with tamoxifen

abnormal circulating chemokine level ( J:305796 )

• mice induced with tamoxifen show a rapid increase in plasma concentration of CXCL10, CXCL12, and CXCL13, with increase of CXCL13 more pronounced than the other two

• levels of CXCL12 and CXCL10 remain stable over a period of 20 days while CXCL13 levels continue to increase after induction

• however, no alteration in the distribution of CXCL12 is seen in the bone marrow

increased circulating CXCL10 level ( J:305796 )

• plasma concentration of CXCL10 is increased following tamoxifen treatment