Phenotypes Associated with This Genotype

Genotype
MGI:6711690

• Allelic Composition: Stk11^tm1.1Rdp/Stk11^tm1.1Rdp; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:305107 )

• dorsal root ganglia explants from E13.5 embryos exhibit reduced axonal growth in vitro compared with control samples

• however, sensory neurons exhibit normal polarization

abnormal axon morphology ( J:305107 )

• E13.5 limbs exhibit strongly reduced overall axonal coverage and total number of axonal branches compared with control limbs

• however, no increase in apoptosis is observed and mitochondria motility is normal

abnormal neuron physiology ( J:305107 )

• reduced axonal ATP levels

cellular

abnormal axon extension ( J:305107 )

• dorsal root ganglia explants from E13.5 embryos exhibit reduced axonal growth in vitro compared with control samples

• however, sensory neurons exhibit normal polarization