Analysis Tools
hematopoietic system
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• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection develop anemia with increased mean corpuscular volume and red blood cell distribution width
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• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection exhibit reduced white blood cell count, with a reduction in lymphocytes, granulocytes, and monocytes
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• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection exhibit increased frequency of immature bone marrow progenitors (LSK cells)
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• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection exhibit lineage-committed mature cells that are skewed to myeloid lineages
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• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection show reduced frequency of colony-forming unit erythroid cells and Ter119+CD71+ erythroid progenitors
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• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection show increased mean corpuscular volume
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• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection show increased red blood cell distribution width
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• all lethally irradiated mice transplanted with mutant-derived bone marrow, followed by pIpC injection, develop overt myelodysplastic syndrome, mostly within half a year after pIpC injection, with severe cytopenia and marked trilineage dysplasia
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immune system
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• lethally irradiated mice transplanted with mutant bone marrow cells followed by pIpC injection exhibit reduced white blood cell count, with a reduction in lymphocytes, granulocytes, and monocytes
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