Phenotypes for Cd19 Fas Hspa13 MGI:6694199 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fas^lpr/Fas^lpr Hspa13^tm1.1Smoc/Hspa13^tm1.1Smoc Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S * C57BL/6 * MRL/Mp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Fas^lpr mutation (39 available); any Fas mutation (83 available)
Hspa13^tm1.1Smoc mutation (0 available); any Hspa13 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to systemic lupus erythematosus ( J:303927 )

• mice exhibit reduced increase in autoantibody levels and proteinuria levels compared with control mice

decreased autoantibody level ( J:303927 )

• compared with Fas^lpr homozygotes

renal/urinary system

increased urine protein level ( J:303927 )

• not as severe as in Fas^lpr homozygotes

homeostasis/metabolism

increased urine protein level ( J:303927 )

• not as severe as in Fas^lpr homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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